Coronavirus live news: US sees muted Thanksgiving day as hospitalisations soar

US reports more than 180,000 cases as holiday begins; 99% of England’s population face tough new curbs; Asta Zeneca likely to begin new trial of vaccine. Follow the developments live

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1.08am GMT

A tale of two cities:

As Matt Hancock put the final touches to England’s new lockdown regime on Wednesday night, the mood of leaders in Manchester and Liverpool could not have been more different.

Related: A tale of two cities: Manchester, Liverpool and the journey of Covid tiers

12.38am GMT

Sadiq al-Mahdi, Sudan’s last democratically elected leader and the great-grandson of the messianic figure who fought the British in the 19th century, has died from the coronavirus, Reuters reports.

Mahdi, who was a central figure in Sudan’s political and spiritual life for more than half a century, was being treated in the United Arab Emirates.

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